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ACRP ACRP-CP Exam Syllabus Topics:

SectionWeightObjectives
Ethical and Participant Safety Considerations19%- Safety monitoring and reporting
  • 1. Safety information evaluation and communication
  • 2. Adverse event identification and classification
- Clinical care and management of research participants
  • 1. Continuity of medical care
  • 2. Informed consent development and review
  • 3. Standard of care vs protocol requirements
- Ethical principles
  • 1. Clinical equipoise and therapeutic misconception
  • 2. Human subject protections and privacy
Study Design and Conduct17%- Study implementation
  • 1. Investigational product management
  • 2. Site selection and activation
  • 3. Study monitoring and oversight
- Study planning
  • 1. Protocol development and amendments
  • 2. Sample size and statistical considerations
  • 3. Study population and eligibility criteria
Regulatory and Compliance Requirements17%- Compliance procedures
  • 1. Audits and inspections
  • 2. Regulatory submissions and approvals
- International standards
  • 1. Declaration of Helsinki
- ICH Guidelines
  • 1. E6(R2)/E6(R3) Good Clinical Practice
  • 2. E9 Statistical Principles
  • 3. E8 General Considerations for Clinical Trials
  • 4. E11 Pediatric Trials
  • 5. E2A Expedited Reporting
Clinical Study Operations15%- Project management
  • 1. Vendor and stakeholder management
  • 2. Timeline and budget management
- Site management
  • 1. Site personnel training and delegation
  • 2. Study documentation and record keeping
Professionalism and Ethical Practice15%- Professional standards
  • 1. Role responsibilities and boundaries
  • 2. Confidentiality and conflict of interest
- Continuous improvement
  • 1. Professional development and education
  • 2. Quality assurance and process improvement
Data Management and Informatics17%- Data reporting
  • 1. Data integrity and security
  • 2. Database lock and data transfer
- Data collection
  • 1. Case report form design and completion
  • 2. Electronic data capture systems
- Data quality control
  • 1. Data validation and cleaning
  • 2. Query management and resolution

ACRP Certified Professional Sample Questions:

Question 1

Which of the following activities would be undertaken by the sponsor to BEST ensure overall quality of the study data?

A. Ensure submission of a data management plan to the regulatory authorities.
B. Ensure there is an accompanying written record that describes the consent process.
C. Develop a plan that describes the monitoring approach for a clinical study.
D. Conduct annual reviews of the protocol and accompanying study documents.


Question 2

Per the protocol, participants' blood creatinine level must be no greater than 2.5 times the upper limit of normal (0.7-1.2 mg/dL). What is the maximum creatinine level the participant can have and be eligible for the trial?

A. 3.6 mg/dL
B. 2.6 mg/dL
C. 3.0 mg/dL
D. 1.8 mg/dL


Question 3

Which of the following statements is TRUE about an EDC system?

A. IRB/IEC approval is required before the use of the computerized system.
B. The eCRF should be an exact page-by-page replica of the paper CRF.
C. A separate workstation should be made available for the monitor.
D. There should be an audit trail to track data entries, deletions, and changes.


Question 4

An impartial witness should be present during the entire informed consent discussion when:

A. A parent/guardian is consenting for a minor subject.
B. An interpreter is translating the consent form for a subject.
C. A legally acceptable representative is unable to read.
D. A subject has been determined to be vulnerable.


Question 5

While reviewing a new protocol, a PI realizes a specialized laboratory test is required that the local hospital does not perform. The PI locates a laboratory that performs the specialized test and retains their services.
Responsibility for ensuring the laboratory retained is qualified for this trial-related task lies with the:

A. CRO
B. Sponsor
C. PI
D. CRC


Solutions:

Question 1
Answer: C
Question 2
Answer: C
Question 3
Answer: D
Question 4
Answer: C
Question 5
Answer: C

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